Evaluation of Modified Early Warning Score Combined with Procalcitonin and D-Dimer in the Early Diagnosis and Prognosis of Sepsis in the Elderly

Gang Zhao; Hongping Yu

doi:doi:10.11648/j.sd.20221004.11

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Evaluation of Modified Early Warning Score Combined with Procalcitonin and D-Dimer in the Early Diagnosis and Prognosis of Sepsis in the Elderly

Gang Zhao, Hongping Yu

Published in Science Discovery (Volume 10, Issue 4)

Received: 15 May 2022 Accepted: 17 June 2022 Published: 27 June 2022

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Abstract

Objective To explore the value of modified early warning score (MEWS) combined with procalcitonin (PCT) and D-Dimer (D-D) in evaluating the condition and prognosis of elderly patients with sepsis. Methods A retrospective study was conducted to collect the data of elderly patients (aged ≥ 60 years) who were hospitalized in Shanghai Fifth rehabilitation hospital and diagnosed with sepsis from January 2016 to June 2020. The MEWS score at admission, PCT, D-D, sequential organ failure score (SOFA) within 24 hours and the 28 day prognosis were recorded. The patients were divided into groups according to the severity of the disease and the 28 day prognosis, and the index differences among the groups were compared; To analyze the prognostic value of the above indexes alone or in combination in elderly patients with sepsis. Results 105 patients were divided into sepsis group (75 cases) and septic shock group (30 cases); According to the 28 day prognosis, the patients were divided into survival group (71 cases) and death group (34 cases). The scores of MEWS, PCT, D-D and SOFA in septic shock group were significantly higher than those in sepsis group (all P < 0.05). The scores of MEWS, PCT, D-D and SOFA in the death group were significantly higher than those in the survival group (all P < 0.01). ROC curve analysis showed that the area under the ROC curve (AUC) of MEWS score, PCT, D-D, SOFA score and MEWS+PCT+D-D score were 0.662, 0.683, 0.626, 0.698 and 0.720 respectively, indicating that all indicators have a certain predictive value for the 28d prognosis of elderly patients with sepsis, and the combination of the three has the greatest predictive value. Conclusion MEWS score is a convenient and rapid scoring system. It can evaluate the condition and prognosis of elderly patients with sepsis together with PCT and D-D.

Published in	Science Discovery (Volume 10, Issue 4)
DOI	10.11648/j.sd.20221004.11
Page(s)	204-208
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Modified Early Warning Score (MEWS), Procalcitonin (PCT), D-Dimers (D-D), Aged, Sepsis

References

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APA Style

Gang Zhao, Hongping Yu. (2022). Evaluation of Modified Early Warning Score Combined with Procalcitonin and D-Dimer in the Early Diagnosis and Prognosis of Sepsis in the Elderly. Science Discovery, 10(4), 204-208. https://doi.org/10.11648/j.sd.20221004.11

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ACS Style

Gang Zhao; Hongping Yu. Evaluation of Modified Early Warning Score Combined with Procalcitonin and D-Dimer in the Early Diagnosis and Prognosis of Sepsis in the Elderly. Sci. Discov. 2022, 10(4), 204-208. doi: 10.11648/j.sd.20221004.11

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AMA Style

Gang Zhao, Hongping Yu. Evaluation of Modified Early Warning Score Combined with Procalcitonin and D-Dimer in the Early Diagnosis and Prognosis of Sepsis in the Elderly. Sci Discov. 2022;10(4):204-208. doi: 10.11648/j.sd.20221004.11

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@article{10.11648/j.sd.20221004.11,
  author = {Gang Zhao and Hongping Yu},
  title = {Evaluation of Modified Early Warning Score Combined with Procalcitonin and D-Dimer in the Early Diagnosis and Prognosis of Sepsis in the Elderly},
  journal = {Science Discovery},
  volume = {10},
  number = {4},
  pages = {204-208},
  doi = {10.11648/j.sd.20221004.11},
  url = {https://doi.org/10.11648/j.sd.20221004.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20221004.11},
  abstract = {Objective To explore the value of modified early warning score (MEWS) combined with procalcitonin (PCT) and D-Dimer (D-D) in evaluating the condition and prognosis of elderly patients with sepsis. Methods A retrospective study was conducted to collect the data of elderly patients (aged ≥ 60 years) who were hospitalized in Shanghai Fifth rehabilitation hospital and diagnosed with sepsis from January 2016 to June 2020. The MEWS score at admission, PCT, D-D, sequential organ failure score (SOFA) within 24 hours and the 28 day prognosis were recorded. The patients were divided into groups according to the severity of the disease and the 28 day prognosis, and the index differences among the groups were compared; To analyze the prognostic value of the above indexes alone or in combination in elderly patients with sepsis. Results 105 patients were divided into sepsis group (75 cases) and septic shock group (30 cases); According to the 28 day prognosis, the patients were divided into survival group (71 cases) and death group (34 cases). The scores of MEWS, PCT, D-D and SOFA in septic shock group were significantly higher than those in sepsis group (all P Conclusion MEWS score is a convenient and rapid scoring system. It can evaluate the condition and prognosis of elderly patients with sepsis together with PCT and D-D.},
 year = {2022}
}

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TY  - JOUR
T1  - Evaluation of Modified Early Warning Score Combined with Procalcitonin and D-Dimer in the Early Diagnosis and Prognosis of Sepsis in the Elderly
AU  - Gang Zhao
AU  - Hongping Yu
Y1  - 2022/06/27
PY  - 2022
N1  - https://doi.org/10.11648/j.sd.20221004.11
DO  - 10.11648/j.sd.20221004.11
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 204
EP  - 208
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20221004.11
AB  - Objective To explore the value of modified early warning score (MEWS) combined with procalcitonin (PCT) and D-Dimer (D-D) in evaluating the condition and prognosis of elderly patients with sepsis. Methods A retrospective study was conducted to collect the data of elderly patients (aged ≥ 60 years) who were hospitalized in Shanghai Fifth rehabilitation hospital and diagnosed with sepsis from January 2016 to June 2020. The MEWS score at admission, PCT, D-D, sequential organ failure score (SOFA) within 24 hours and the 28 day prognosis were recorded. The patients were divided into groups according to the severity of the disease and the 28 day prognosis, and the index differences among the groups were compared; To analyze the prognostic value of the above indexes alone or in combination in elderly patients with sepsis. Results 105 patients were divided into sepsis group (75 cases) and septic shock group (30 cases); According to the 28 day prognosis, the patients were divided into survival group (71 cases) and death group (34 cases). The scores of MEWS, PCT, D-D and SOFA in septic shock group were significantly higher than those in sepsis group (all P Conclusion MEWS score is a convenient and rapid scoring system. It can evaluate the condition and prognosis of elderly patients with sepsis together with PCT and D-D.
VL  - 10
IS  - 4
ER  -

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Author Information

Gang Zhao

Department of Geriatric Medcine, Shanghai Fifth Rehabilitation Hospital, Shanghai, China
Hongping Yu

Infectious Disease Department, Songjiang District Cratral Hospital, Shanghai, China

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Plain Text BibTeX RIS

APA Style

Gang Zhao, Hongping Yu. (2022). Evaluation of Modified Early Warning Score Combined with Procalcitonin and D-Dimer in the Early Diagnosis and Prognosis of Sepsis in the Elderly. Science Discovery, 10(4), 204-208. https://doi.org/10.11648/j.sd.20221004.11

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ACS Style

Gang Zhao; Hongping Yu. Evaluation of Modified Early Warning Score Combined with Procalcitonin and D-Dimer in the Early Diagnosis and Prognosis of Sepsis in the Elderly. Sci. Discov. 2022, 10(4), 204-208. doi: 10.11648/j.sd.20221004.11

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AMA Style

Gang Zhao, Hongping Yu. Evaluation of Modified Early Warning Score Combined with Procalcitonin and D-Dimer in the Early Diagnosis and Prognosis of Sepsis in the Elderly. Sci Discov. 2022;10(4):204-208. doi: 10.11648/j.sd.20221004.11

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@article{10.11648/j.sd.20221004.11,
  author = {Gang Zhao and Hongping Yu},
  title = {Evaluation of Modified Early Warning Score Combined with Procalcitonin and D-Dimer in the Early Diagnosis and Prognosis of Sepsis in the Elderly},
  journal = {Science Discovery},
  volume = {10},
  number = {4},
  pages = {204-208},
  doi = {10.11648/j.sd.20221004.11},
  url = {https://doi.org/10.11648/j.sd.20221004.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20221004.11},
  abstract = {Objective To explore the value of modified early warning score (MEWS) combined with procalcitonin (PCT) and D-Dimer (D-D) in evaluating the condition and prognosis of elderly patients with sepsis. Methods A retrospective study was conducted to collect the data of elderly patients (aged ≥ 60 years) who were hospitalized in Shanghai Fifth rehabilitation hospital and diagnosed with sepsis from January 2016 to June 2020. The MEWS score at admission, PCT, D-D, sequential organ failure score (SOFA) within 24 hours and the 28 day prognosis were recorded. The patients were divided into groups according to the severity of the disease and the 28 day prognosis, and the index differences among the groups were compared; To analyze the prognostic value of the above indexes alone or in combination in elderly patients with sepsis. Results 105 patients were divided into sepsis group (75 cases) and septic shock group (30 cases); According to the 28 day prognosis, the patients were divided into survival group (71 cases) and death group (34 cases). The scores of MEWS, PCT, D-D and SOFA in septic shock group were significantly higher than those in sepsis group (all P Conclusion MEWS score is a convenient and rapid scoring system. It can evaluate the condition and prognosis of elderly patients with sepsis together with PCT and D-D.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Evaluation of Modified Early Warning Score Combined with Procalcitonin and D-Dimer in the Early Diagnosis and Prognosis of Sepsis in the Elderly
AU  - Gang Zhao
AU  - Hongping Yu
Y1  - 2022/06/27
PY  - 2022
N1  - https://doi.org/10.11648/j.sd.20221004.11
DO  - 10.11648/j.sd.20221004.11
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 204
EP  - 208
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20221004.11
AB  - Objective To explore the value of modified early warning score (MEWS) combined with procalcitonin (PCT) and D-Dimer (D-D) in evaluating the condition and prognosis of elderly patients with sepsis. Methods A retrospective study was conducted to collect the data of elderly patients (aged ≥ 60 years) who were hospitalized in Shanghai Fifth rehabilitation hospital and diagnosed with sepsis from January 2016 to June 2020. The MEWS score at admission, PCT, D-D, sequential organ failure score (SOFA) within 24 hours and the 28 day prognosis were recorded. The patients were divided into groups according to the severity of the disease and the 28 day prognosis, and the index differences among the groups were compared; To analyze the prognostic value of the above indexes alone or in combination in elderly patients with sepsis. Results 105 patients were divided into sepsis group (75 cases) and septic shock group (30 cases); According to the 28 day prognosis, the patients were divided into survival group (71 cases) and death group (34 cases). The scores of MEWS, PCT, D-D and SOFA in septic shock group were significantly higher than those in sepsis group (all P Conclusion MEWS score is a convenient and rapid scoring system. It can evaluate the condition and prognosis of elderly patients with sepsis together with PCT and D-D.
VL  - 10
IS  - 4
ER  -

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